See Grants.gov Spring 2008 newsletter http://www.grants.gov/assets/GrantSpringNewsletter08.pdf for information on:

(1) System Enhancements and New Functionality
(2) Tips for Preventing Grant Fraud
(3) Using Grants.gov Compatible Software
(4) Applicant Tips and Other Resources Available to Help with the Grant Process

Grants.gov reminder from RSP: Cayuse provides UW applicants a forms independent way to submit applications to Grants.gov. CALS requires that you use Cayuse for any Grants.gov submissions that are supported by Cayuse. Unfortunately, there are some programs that Cayuse does not yet support — information about these programs is available at: http://www.rsp.wisc.edu/cayuse/index.html

If your program is not supported, you will need to use the form set available for download at Grants.gov. These forms are transitioning from PureEdge to Adobe. Adobe however is VERY sensitive to what version is used to download, open, edit & submit the application. Much information is circulating in the community about the correct version of the forms required. Information posted at:
http://www.dartmouth.edu/%7Eosp/resources/grants-dot-gov/AdobeReader811_812.pdf provides some guidance. Grants.gov has also posted information on their site: http://www.grants.gov/help/general_faqs.jsp#88 providing information about the appropriate version.